This is just here as a test because I lose it
Term information
Synonym
"ERK1/2 cascade"
ERK Cascade
ERK signaling pathway
ERK pathway
ERK signaling
ERK signal pathway
ERK signal transduction pathway
DAG-PKC-ERK pathway
ERK signaling cascade
"ERK1 and ERK2 cascade"
def
"A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases.\nNote that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases." [GO:0070371]
Term relations
Subclass of:
- MAPKKK cascade
- part of some B cell receptor signaling (through Ras and ERK cascade)
- part of some FGFR1 signaling pathway
- part of some Cell growth
- part of some TPO signaling pathway (through Sos, Ras and Erk cascade)
- part of some PDGF receptor signaling pathway
- part of some Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta)
- part of some EGF receptor signaling pathway
- part of some Heterotrimeric GPCR signaling pathway (through G alpha q and PLC beta)
- part of some RTK signaling pathway
- part of some Heterotrimeric GPCR signaling pathway (through G alpha s)
- part of some VEGF receptor signaling pathway
- part of some Insulin receptor signaling pathway (through IRS mediated signaling)
- part of some Cell differentiation
- part of some FGF receptor signaling pathway
- part of some Insulin receptor signaling pathway (through Shc mediated signaling)
- part of some PDGF signaling pathway (through Grb2, Sos, Ras and Erk cascade)
- part of some Cell proliferation
- part of some NGF receptor signaling pathway
- part of some Integrin signaling pathway (through ERK cascade)
- part of some CD4 T cell receptor signaling (through Ras and ERK cascade)
- part of some HGF receptor signaling pathway