Proteases that contain proteolytic core domains and ATPase-containing regulatory domains. They are usually comprised of large multi-subunit assemblies. The domains can occur within a single peptide chain or on distinct subunits.

Synonyms: ATP Dependent Proteases, ATP-Requiring Protease, Proteases, ATP-Dependent, Adenosine Triphosphate-Dependent Proteolytic System, Protease, ATP-Dependent, EC 3.4.21.-, Adenosine Triphosphate Dependent Proteolytic System, ATP-Dependent Protease, ATP Requiring Protease, Protease, ATP-Requiring, ATP-Dependent Proteases, ATP Dependent Protease