An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Synonyms: 11-beta-Hydroxysteroid Dehydrogenase Type 2, 11 beta-HSD2, 11beta-Hydroxysteroid Dehydrogenase Type 2, 11beta-HSD2, 11 beta-Hydroxysteroid Dehydrogenase Type 2, EC 1.1.1.146, 11beta-HSD2 Reductase, 11 beta Hydroxysteroid Dehydrogenase Type 2, 11beta Hydroxysteroid Dehydrogenase Type 2
Instance information
2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003 ,2004; 11 BETA-HSD2 was indexed under HYDROXYSTEROID DEHYDROGENASES 1992-2003
D043209