1-Alkyl-2-acetylglycerophosphocholine Esterase
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A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Synonyms: Lipoprotein-Associated Phospholipase A2, Hydrolase, Platelet-Activating Factor, Acetylhydrolase II, PAF, Lp-PLA2, PAF Acetylhydrolase II, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Factor Hydrolase, Platelet-Activating, Lipoprotein Associated Phospholipase A2, Platelet activating Factor Acetylhydrolase IB, Lp-PLA(2), Esterase, 1-Alkyl-2-acetylglycerophosphocholine, PAF 2-Acylhydrolase, PAF 2-Acetylhydrolase, Platelet Activating Factor Hydrolase, Lp PLA2, Platelet-activating Factor Acetylhydrolase IB, PAF Acetylhydrolase, PAF 2 Acylhydrolase, 1 Alkyl 2 acetylglycerophosphocholine Esterase, Phospholipase A2, Lipoprotein-Associated, Platelet-Activating Factor Hydrolase, EC 3.1.1.47, PAF 2 Acetylhydrolase, 2-Acetylhydrolase, PAF, Lipoprotein-Associated Phospholipase A(2), Acetylhydrolase, PAF
Instance information
/antag: coordinate with PHOSPHOLIPASE A2 INHIBITORS ,2004; 1-ALKYL-2-ACETYLGLYCEROLPHOSPHOCHOLINE ESTERASE was indexed under PHOSPHOLIPASES A 1983-2003; LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 was indexed under PHOSPHOLIPASES A 2000-2007 & under 1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE 2007 ,2004(1983)
D043203