Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.

Synonyms: 11-Reductase, Corticosteroid, 11 beta Hydroxysteroid Dehydrogenases, 11 Hydroxysteroid Dehydrogenase, Dehydrogenase, 11B-Hydroxysteroid, 11-Hydroxysteroid Dehydrogenase, Corticosteroid 11-Oxidoreductase, 11B-Hydroxysteroid Dehydrogenase, 11B Hydroxysteroid Dehydrogenase, 11-Oxoreductase, Cortisone, 11beta-Hydroxysteroid Dehydrogenase, beta-Hydroxysteroid Dehydrogenase, 11, 11 beta Hydroxysteroid Dehydrogenase, Cortisone 11-Oxoreductase, Dehydrogenase, 11-Hydroxysteroid, Dehydrogenase, 11 beta-Hydroxysteroid, Corticosteroid 11-Reductase, Dehydrogenase, 11beta-Hydroxysteroid, Cortisone 11 Oxoreductase, Corticosteroid 11 Oxidoreductase, EC 1.1.1.146, 11-beta-Hydroxysteroid Dehydrogenases, 11-Oxidoreductase, Corticosteroid, Corticosteroid 11 Reductase, Dehydrogenases, 11-beta-Hydroxysteroid, 11beta Hydroxysteroid Dehydrogenase, 11 beta-Hydroxysteroid Dehydrogenase