ATP Binding Cassette Transporter, Subfamily B
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A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
Synonyms: 0, ATP Binding Cassette, Sub Family B Proteins, P-Glycoproteins, P Glycoproteins, ATP Binding Cassette Transporter, Sub Family B, ATP-Binding Cassette, Sub-Family B Proteins, Multidrug Resistance Proteins, ATP Binding Cassette Transporter, Sub-Family B, ATP Binding Cassette Transporter, Subfamily B
Instance information
note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available ,2019 (1999); use P-GLYCOPROTEIN 1995-1998 ,2019; see ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B 2018; see P-GLYCOPROTEIN 1995-1998; P-GLYCOPROTEIN was indexed under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-1994, GLYCOPROTEINS 1980-1987, and MEMBRANE PROTEINS 1980-1982
D018435