A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Synonyms: EC 1.14.15.18, 25-Hydroxyvitamin D2 1-hydroxylase, 25 Hydroxyvitamin D 1 alpha Hydroxylase, Calcidiol 1 Monooxygenase, 25-Hydroxycholecalciferol-1-Hydroxylase, 25 Hydroxyvitamin D3 1 alpha Hydroxylase, 25 Hydroxycholecalciferol 1 Hydroxylase, Cytochrome P 450 CYP27B1, 1-hydroxylase, 25-Hydroxyvitamin D2, 25-Hydroxycholecalciferol 1-Hydroxylase, 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol, 25 Hydroxyergocalciferol 1 alpha Hydroxylase, 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Cytochrome P-450 CYP27B1, CYP27B1, 1-alpha-Hydroxylase, 25-Hydroxyvitamin D, 25-Hydroxyergocalciferol 1-alpha-Hydroxylase, 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase, 25 Hydroxyvitamin D2 1 hydroxylase, Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating), 25-Hydroxyvitamin D 1-alpha-Hydroxylase, Calcidiol 1-Monooxygenase
Instance information
2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002 ,2003; see 25-HYDROXYCHOLECALCIFEROL 1-HYDROXYLASE 1991-2002, see STEROID HYDROXYLASES 1975-1990; 25-HYDROXYVITAMIN D2 1-HYDROXYLASE was indexed under STEROID HYDROXYLASES 1976-2002
D015090