Drug formulations or delivery systems intended to discourage the abuse of CONTROLLED SUBSTANCES. These may include physical barriers to prevent chewing or crushing the drug; chemical barriers that prevent extraction of psychoactive ingredients; agonist-antagonist combinations to reduce euphoria associated with abuse; aversion, where controlled substances are combined with others that will produce an unpleasant effect if the patient manipulates the dosage form or exceeds the recommended dose; delivery systems that are resistant to abuse such as implants; or combinations of these methods.

Synonyms: 0, Abuse Deterrent Formulation, Abuse-Deterrent Formulation, Formulations, Abuse-Deterrent, Formulation, Abuse-Deterrent, Abuse-Deterrent Formulations, Abuse Deterrent Formulations