Highly conserved amino acid motifs that occur in ATP-binding proteins, especially AAA ATPases. They are characterized by the pattern G-x(4)-GK-[TS]; G, K, T and S are GLYCINE; LYSINE; THREONINE; and SERINE, where x can be any amino acid. This motif binds the beta-phosphate of nucleotides.

An approximately 250 amino acid domain common to AAA ATPases and AAA Proteins. It consists of a highly conserved N-terminal P-Loop ATPase subdomain with an alpha-beta-alpha conformation, and a less-conserved C-terminal subdomain with an all alpha conformation. The N-terminal subdomain includes Walker A and Walker B motifs which function in ATP binding and hydrolysis.

Synonyms: AAA Module, Walker A Motif, A-Loops, B Motif, Walker, Motifs, Walker, P-Loop, Walker Motif, Walker Motifs, Domain, AAA+, AAA Domain, A Loop, AAA+ Domain, Domains, AAA+, A-Loop, Module, AAA, Domain, AAA, AAA+ Module, A Motif, Walker, Motif, Walker B, AAA+ Modules, Motif, Walker A, Modules, AAA+, Walker B Motif, AAA Domains, AAA+ Domains, P-Loops, Module, AAA+, Domains, AAA, AAA Modules, Motif, Walker, Modules, AAA, P Loop