A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.

Synonyms: ADAM17 Protein, Disintegrin and Metalloproteinase Domain-Containing Protein 17, ADAM 17 Protein, TNF-alpha Converting Enzyme, Tumor Necrosis Factor-alpha Convertase, TNF alpha Convertase, Tumor Necrosis Factor Alpha Convertase, EC 3.4.24.86, TNF alpha Converting Enzyme, Disintegrin and Metalloproteinase Domain Containing Protein 17, Tumor Necrosis Factor alpha Converting Enzyme, Tumor Necrosis Factor-alpha Converting Enzyme, ADAM-17, Convertase, TNF-alpha, CD156b Antigen, Antigen, CD156b, ADAM-17 Protein, TNF-alpha Convertase, TACE (Enzyme), TACA (Enzyme)

Instance information

comment

2017 (1996) ,2017; ADAM17 PROTEIN was indexed under ADAM PROTEINS 2005-2016, and under METALLOENDOPEPTIDASES 1996-2005

identifier

D000072198

Instance relations