An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.

Synonyms: APOBEC Related Protein, APOBEC-Related Cytidine Deaminase, APOBEC3G Protein, APOBEC-3G Protein, APOBEC Related Cytidine Deaminase, CEM15 Protein, APOBEC-3G Deaminase, EC 3.5.4.5, Cytidine Deaminase, APOBEC-Related, APOBEC-Related Protein, Deaminase, APOBEC-3G, APOBEC3G Deaminase, Deaminase, APOBEC3G, APOBEC 3G dC dU Editing Enzyme, APOBEC 3G Protein, APOBEC 3G Deaminase, APOBEC-3G dC-dU Editing Enzyme

Instance information

comment

2017

identifier

D000071480

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