An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction of aggrecan in ARTHRITIS.
Synonyms: Aggrecanase 1, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein, EC 3.4.24.82, Aggrecanase-1, ADAMTS-4 Protein, ADAMTS 4 Protein, ADAMTS4 Protein
Instance information
comment
2017; ADAMTS4 PROTEIN was indexed under PROCOLLAGEN N-ENDOPEPTIDASE and ADAM PROTEINS 2006-2016; and under METALLOENDOPEPTIDASES 1999-2005 ,2017 (1999)
identifier
D000071121