An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA.

Synonyms: von Willebrand Factor Cleaving Protease, vWF Cleaving Protease, vWF-Cleaving Protease, A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein, EC 3.4.24.87, ADAMTS 13 Protein, von Willebrand Factor-Cleaving Protease, ADAMTS13 Protein, ADAMTS13 Protease, ADAMTS-13 Protein

Instance information

comment

2017

identifier

D000071120