An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.

Synonyms: ADAMTS 5 Protein, Aggrecanase 2, ADAMTS5 Protein, ADAMTS5 Protease, ADAMTS11 Protein, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein, Aggrecanase-2, EC 3.4.24.-, ADAMTS-5 Protein